Description
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100uM); causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts